Jul 2026
Abstract B046: A first-in-class Pin1 degrader provides robust PKPD response and efficacy in PDAC models
The prolyl isomerase Pin1 is a critical regulator of protein conformation and is frequently overexpressed across a spectrum of human malignancies. Its enzymatic activity is essential for stabilizing numerous oncogenic client proteins while promoting the turnover of key tumor suppressors, thereby driving neoplasti...
Morgan B. O'Shea, Guosen B. Ye, Melvyn B. Chow et al.
· Clinical Cancer Research · 0 citations