Nov 2026
Abstract 6313: Integration of Genomic and Lab Data with Dynamic EHR Modeling
Background: Polygenic risk scores (PRS) for cardiovascular disease are almost always used as static covariates in proportional-hazards (PH) models - a single number, fixed for life. However, genetic effects on coronary artery disease (CAD) and other CV outcomes are non-stationary, rising and falling with age; when g...
S. Urbut, Giovanni Parmigiani, Alexander Gusev et al.
· Circulation · 0 citations