Pramod K. Srivastava

Activity in vivo of in vitro expanded and adoptively transferred antigen-specific CD8+ T cells against neoepitopes that mediate tumor rejection 2306826

A subset of somatic passenger mutations in cancer cells lead to generation of peptides which can be presented by MHC I molecules and recognized by CD8 T cells. Such peptides are tumor- specific and are termed neoepitopes. A small subset of neoepitopes can immunize mice against tumors in models of prophylaxis and...