Peptide Fingerprinting of Single Protein Molecules Using In-Plane Nanopore Sensors Integrated to an Extended Immobilized Nanoscale Enzymatic Reactor (eINER).
We report a thermoplastic nanofluidic device that combines an extended immobilized nanoscale enzymatic reactor (eINER) with a dual in-plane nanopore time-of-flight (DNP-ToF) reader for label-free peptide fingerprinting of single protein molecules. As opposed to traditional membrane-based nanopores, the DNP-ToF reader u...