Prbhuv Nigam

Kūkulu: Diffusion-Based Reconstruction of Antibody CDR Loops using a Structure-Aware Joint Embedding Predictive Architecture

Antibody complementarity-determining regions (CDRs), especially CDR-H3, are a dominant source of binding specificity but remain difficult to design due to coupled sequence-structure constraints and local geometric variability. Here we present Kukulu, a structure-aware Joint Embedding Predictive Architecture (JEPA) comb...