Introduction Maternal Embryonic Leucine Zipper Kinase (MELK) is a key regulator of the G2/M checkpoint and a recognized pan-cancer oncogene; however, its regulatory mechanisms and clinical significance in lung adenocarcinoma (LUAD) remain incompletely understood. This study aimed to investigate the molecular, prognosti...
Kritika Jangir, Niranjan Kumar, Chainsee Saini et al.· Frontiers in Oncology· 0 citations
Cells undergo tight regulation during the mitotic phase of the cell cycle, which produces genetically identical daughter cells and prevents the segregation of duplicate chromosomes. This regulatory network has identified maternal embryonic leucine zipper kinase (MELK) as a proliferation-associated regulator. MELK is hi...
Kritika Jangir, Prachi Patidar, B. Baweja et al.· Frontiers in Oncology· 0 citations
This review consolidates current knowledge of TTK function beyond its canonical SAC activity, emphasizing its emerging roles in DNA damage response, epithelial-mesenchymal transition, and oncogenic signaling pathways.
Prachi Patidar, Kritika Jangir, Chainsee Saini et al.· Cell Communication and Signa...· 0 citations
A robust G2/M -associated regulatory framework in LUAD is defined, characterized by reciprocal dysregulation of oncogenes and tumor suppressors and associated with the predicted TMPO-AS1–hsa-let-7b-5p regulatory network, which is linked to a less immunosuppressive tumor microenvironment, offering potential prognostic a...
