The isopentenol utilization pathway: enzyme engineering, metabolic integration, and applications in microbial terpenoid biosynthesis.
Terpenoids are among the most structurally diverse and commercially important natural products, with applications in pharmaceuticals, flavors, fragrances, and biofuels. Controllable supply of the universal precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) remains a central limitation for mi...