DEVELOPMENT AND VALIDATION OF AN RP-HPLC BIOANALYTICAL METHOD FOR QUANTIFICATION OF RIZATRIPTAN BENZOATE IN RAT PLASMA AND BRAIN HOMOGENATE: APPLICATION TO PHARMACOKINETIC AND BRAIN-TARGETING STUDIES
Purpose This study was conducted to establish and validate a new, rapid, specific, sensitive and reproducible reverse-phase high performance liquid chromatographic (RP-HPLC) method for the determination of Rizatriptan Benzoate (RZT) in rat plasma and brain homogenate. The validated method was then used to assess the PK...