Pryscila D. S. Teixeira

Hepatic translational rewiring in insulin deficiency identifies Reg3α as an insulin-independent glucoregulatory factor

Abstract Context Insulin deficiency (ID) causes severe metabolic defects and death if untreated, while insulin therapy does not fully restore metabolic homeostasis. Leptin therapy corrects metabolic abnormalities and promotes survival in rodents unable to produce insulin, suggesting the existence of insulin-independent...