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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Pumin Zhang

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2 papers indexed here

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Open access Sep 2026

DDX3X regulates DNA repair pathway choice at double-strand breaks via RNA-DNA hybrid formation.

DNA Double-strand breaks (DSBs) are amongst the most cytotoxic DNA lesions. During the processing of DSBs, so-called Break-Induced RNA-DNA Hybrids (BIRDHs) are generated to promote timely DSB repair. Here, we identify the DEAD-box helicase DDX3X as a positive regulator of BIRDHs and a key factor in facilitating DSB rep...

Wei Wu, Meng-Jiao Lan, Juan Zhang et al. · 0 citations
Open access Aug 2026

OTUD5 maintains STAT1/2 stability and promotes IFNγ-driven intestinal inflammation

Using an intestinal epithelial cell -specific Otud5 KO mouse model, it is shown that Otud5 deficiency significantly alleviated the IFNγ-dependent colitis induced by dextran sulfate sodium, as evidenced by reduced weight loss and diminished infiltration of Ly6C+ inflammatory monocytes.

Huiyuan Guan, Changzhou Cai, Jiewei Wang et al. · 0 citations

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