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Puneet Kumar

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Open access Aug 2026

Structural and mechanistic analysis of semisynthetic α-mangostin derivatives with anticancer activity via topoisomerase II inhibition.

Eleven novel alkyl/arylalkyl substituted α-mangostin derivatives (M2-M12) were synthesized from isolated α-mangostin (M1) from the pericarp of Garcinia mangostana L. extract. Among all the compounds, M10 exhibited the most potent antiproliferative activity against MCF-7 cells, with an IC₅₀ of 8.39 ± 0.07 μM, comparable...

M. K. Katiyar, Faheem Ahmed, Sonali Priyadarshini et al. · 0 citations

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