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Author

Purnima Khandelwal

2 papers indexed here

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Aug 2026

Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors.

Within the tumor microenvironment (TME), regulatory T (Treg) cells promote an immunosuppressive state with limited tumor antigen presentation and antitumor effector T (Teff) cell responses, which can drive resistance to cancer immunotherapies. IKZF2 (Helios) is a transcription factor essential for stabilizing the immun...

E. Cherney, S. Nair, Suresh Babu Viswa Krishna Penmetsa et al. · 0 citations
Sep 2026

Automated High-Throughput Ligand-Detected NMR for Medicinal Chemistry Hit Triage and Binding Assessment

Early discovery campaigns routinely generate screening hits whose progression is limited by uncertain aqueous solubility, chemical integrity, and target engagement. We report a fully automated, ligand-detected high-throughput NMR (HT-NMR) workflow, applicable to aromatic-ring-containing compounds common to high throu...

Bradley Falk, Luciano Mueller, E. Braunstein et al. · 0 citations

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