Author

Puttachat Poound

3 papers indexed here

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Open access Oct 2026

Multi-omics profiling identifies a metabolic and energetic signature associated with neuronal dENL/AF9 suppression in aged flies

A stronger transcriptional response to neuronal dENL/AF9 suppression in aged flies is identified and a distinct metabolic and energetic molecular signature in aged fly heads is identified, providing candidate molecular correlates of the previously established longevity phenotype and a framework for studies of neuronal...

Ranchana Yeewa, Pitiporn Noisagul, Sivamoke Dissook et al. · bioRxiv · 0 citations

Open access Sep 2026

Pre-symptomatic proteomic and metabolomic profiling identifies compensated ER-redox-metabolic adaptation and early nuclear vulnerability in neuronal ERO1L toxicity

Investigation of how neuronal ERO1L elevation reshapes cellular homeostasis before overt dysfunction in Drosophila melanogaster establishes a pre-symptomatic state in which proteostatic and metabolic adaptation coexists with early vulnerability of nuclear and RNA-homeostasis pathways, preceding overt oxidative stress a...

L. Lo Piccolo, Ranchana Yeewa, Puttachat Poound et al. · bioRxiv · 0 citations

Open access Jul 2026

Context-dependent YEATS-domain inhibition enhances neuronal resilience and improves ALS phenotypes.

The role of the ENL/AF9 YEATS domain is defined using complementary chemical and genetic perturbations and established ENL/AF9 YEATS-domain inhibition as a context-dependent strategy to enhance neuronal resilience with relevance to ALS and related proteotoxic disorders.

Luca Piccolo, Chansunee Panto, Ranchana Yeewa et al. · Neurobiology of Disease · 1 citation