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Open access Oct 2026

Sex differences in lipid management among high-risk patients without prior myocardial infarction or stroke: results from the VESALIUS-REAL global study

Effective lipid-lowering therapy (LLT) reduces the risk of cardiovascular outcomes in patients at high cardiovascular risk, as well as in those without a history of myocardial infarction (MI) or stroke. The VESALIUS-CV trial demonstrated the benefit of intensive low-density lipoprotein cholesterol (LDL-C) lowerin...

Q. Chan, J. Cegla, J. Cornel et al. · 0 citations
Open access Oct 2026

Lipid management in patients with coronary artery disease at risk of a first major atherosclerotic cardiovascular event: findings from the VESALIUS-REAL global study

In this large, global, real-world study, most patients with CAD at risk of a first MACE were undertreated with LLT and did not achieve recommended LDL-C levels, highlighting substantial gaps between guideline recommendations and real-world practice.

Q. Chan, J. Cegla, J. Cornel et al. · 0 citations
Open access Sep 2026

Gaps in lipid management among high-risk patients without prior MI or stroke: the VESALIUS-REAL global study.

Most patients at high CV risk were not optimally managed, with low rates of LLT initiation, treatment intensification, LDL-C monitoring, and LDL-C goal attainment across 11 databases, highlighting a substantial unmet clinical need for improved guideline-based lipid management to prevent first major CV events in high-ri...

Q. Chan, J. Cegla, U. Laufs et al. · 0 citations

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