Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS
Polycystic ovary syndrome (PCOS) represents a major cause of anovulatory infertility worldwide, yet the mechanistic nexus linking metabolic perturbations to follicular microenvironment deterioration remains elusive. This study uncovers a novel pathogenic axis wherein lipotoxicity in metabolically compromised PCOS (M-...