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Author

Q. Luo

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Aug 2026

A novel TK/gE-deleted pseudorabies virus vaccine expressing CCL3L1 enhances humoral immunity by stimulating the dendritic cell-T follicular helper-germinal center axis.

Results demonstrate that CCL3L1 acts as an effective molecular adjuvant by potentiating humoral immunity through activation of the conventional DC-T follicular helper cell-GC B cell axis, supporting HNX-ΔTK/ΔgE-CCL3L1 as a potential vaccine for the control of emerging PRV variants.

Lun Yao, Si-Wen Hao, Chengjun Zhang et al. · 0 citations
Open access Jul 2026

Inhibition of Pseudomonas aeruginosa-secreted protease IV reduces lung inflammation

PpL is established as a key virulence factor that triggers AP-1-mediated inflammatory signaling, structural and functional insights into PrpL inhibition are provided, and AprA is identified as a novel upstream PrpL activator, highlighting PrpL as a promising anti-virulence therapeutic target.

S. Daboor, Lauren D. Burton, Trilok Neupane et al. · 0 citations

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