While the earliest pathological signs of cardiovascular–kidney–metabolic disease (CKMD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of children at high risk. With increasing childhood obesity, early, sensitive detection of CKMD risk is critical to timely interventio...
Joshua M. Landman, Heather M. Highland, A. Perry et al.· Nature Metabolism· 0 citations
Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current diagnostic approaches rely on histology, which exhibits wide diagnostic variability and lacks clinically relevant molecular phenotyping. Here we leverage image-based spatial transcriptomics at subcellu...
Kaushik Amancherla, A. M. Taravella Oill, Xavier Bledsoe et al.· Nature Cardiovascular Resear...· 1 citation
Heart failure (HF) affects 6.7 million people in the US and includes two major subtypes, HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), with distinct genetic architectures. We meta-analyze genome-wide association studies (GWAS) of 38,781 HFrEF cases, 38,163 HFpEF cases, and 5...
Chang Liu, Qin Hui, Gregorio V. Linchangco et al.· Nature Communications· 0 citations
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