Gut microbiota dysbiosis is closely associated with intestinal barrier dysfunction and immune imbalance. This study evaluated the efficacy of Ligilactobacillus salivarius AR809 and its exopolysaccharides (EPS809) in alleviating dysbiosis-associated intestinal dysfunction. In an antibiotic-induced murine model, both...
Shen Li, Yao Chen, Yong-Jun Xia et al.· Food Science and Human Welln...· 0 citations
Abstract Antibiotic exposure is a major driver of gut microbiota dysbiosis, and its effects extend beyond transient diversity loss. Persistent alterations in microbial composition and metabolites disrupt intestinal barrier integrity, immune homeostasis, and host metabolic signaling, thereby increasing the risk of chron...
Hang Guo, Cheng-Cheng Zhang, Rui-Min Wang et al.· Gut microbes· 0 citations
Hyperuricemia (HUA) poses a significant public health challenge, and prolonged use of conventional urate-lowering drugs may result in drug dependence and adverse effects, including hepatic and renal damage. In recent years, probiotics have emerged as a promising focus for uric acid (UA) regulation due to their favo...
Ding-Xu Zhu, Qian Jiang, Lei Sun et al.· Food Science and Human Welln...· 0 citations
The microbiota and metabolic dysbiosis underlying flatulence is revealed, the key regulatory role of F. prausnitzii is highlighted, and the foundation for targeted microbiota-based intervention strategies for flatulence is laid.
Rui-Min Chen, Chuan Zhang, Shi-Kai Yan et al.· Gut microbes· 0 citations
Overall, MmALS represents a data-efficient active learning framework for protein evolution, advancing computational enzyme design by enabling accurate optimization under limited experimental sampling.
Chenlu Zhu, Yu-Cheng Guo, Yu-Jie Yang et al.· ACS Catalysis· 0 citations
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