Whole-Genome Sequencing Reveals the Resistome, Virulome, Pan-Genome Architecture, and Phylogenomic Diversity of Extensively Drug-Resistant Salmonella enterica Serovar Typhi in Pakistan
Background: The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has severely constrained typhoid treatment. Pakistan is a major hotspot for XDR typhoid, yet genomic evidence defining the molecular basis of antimicrobial resistance, virulence, and genomic div...