Author

Qibiao Wu

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Open access Oct 2026

Targeting the HPGDS-PGD2 axis to treat Th17 cell-mediated autoimmunity in multiple sclerosis

Th17 cells are central drivers of autoimmune pathology, including multiple sclerosis (MS), yet the endogenous metabolic signals that shape their pathogenic differentiation remain incompletely defined. Prostaglandin D₂ (PGD2) is traditionally viewed as an extracellular mediator in allergic diseases. Here, we identify PG...

Yu-Xin Zhuang, Kawai Lei, Yan Li et al. · Signal Transduction and Targ... · 0 citations

Sep 2026

Identification of Causal Plasma Proteins and Immune Mediators for Lung Cancer in Never-Smokers: A Large-Scale Integrative Analysis Combining Mendelian Randomization, Colocalization, and Mediation.

OBJECTIVE As global smoking rates decline, Lung Cancer in Never-Smokers (LCINS) has emerged as a distinct and increasingly important clinical entity. However, its underlying pathogenesis remains poorly understood, highlighting the need to identify circulating molecular determinants and candidate biomarkers. METHODS G...

Jian-Cong Wu, Qi Zhang, Yan-Ming Lin et al. · Current Medicinal Chemistry · 0 citations

Review Open access Jul 2026

Hydrogel microspheres for precision biomedicine: network engineering, microfabrication, and therapeutic applications

This review establishes criteria for selecting optimal microfabrication techniques, guiding the evolution of hydrogel microspheres from simple delivery carriers to engineered therapeutic microenvironments through the integrated design of materials and bioengineering.

Yichen Sun, Zixuan Xiao, Xiaoyuan Zhang et al. · RSC Advances · 0 citations