Author

Qi Chen

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Sep 2026

PAM-Free Programmable Enzymatic Cascade Design Enabling Highly Sensitive CRISPR/Cas12a Lateral Flow Assay for Foodborne Pathogen Detection

CRISPR/Cas12a-assisted nucleic acid assays have shown great potential for rapid pathogen detection. However, their implementation in lateral flow assays remains constrained by strict protospacer adjacent motif (PAM) requirements and low-contrast, signal-off readouts. To effectively address these limitations, we prese...

Qi Chen, Zhao-Ran Chen, Yu-Bo Peng et al. · Analytical Chemistry · 0 citations

Dual-Mode Lateral Flow Strip with Förster Resonance Energy Transfer for Rapid and Accurate Thrombin Detection

A dual-aptamer-based, dual-mode FRET lateral flow strip is developed for the rapid and sensitive detection of thrombin in serum samples, achieving a fluorescence-based detection limit of 0.135 nM-twice as sensitive as the colorimetric method.

Qi Chen, Li Yao, Wei Qu et al. · 1 citation