PIWIL4 is a core component of the PIWI/piRNA pathway. Its roles in germ cell development, transposon silencing, and genome stability maintenance are well established. Recent studies have shown that PIWIL4 is abnormally expressed in many cancers. There, it helps regulate key malignant processes—including cell cycle cont...
Qi Deng, Yi Liu, Yang Qu et al.· Frontiers in Oncology· 0 citations
Critically appraising the existing evidence, this work identifies key knowledge gaps, such as the understudied sporadic EOPC subgroup and the lack of dedicated clinical trials, and proposes future research directions to inform early detection and optimize therapeutic strategies for this unique patient population.
This review establishes a comprehensive theoretical framework for understanding the role of ATP5A1 in disease pathogenesis and supports its potential utility in precision diagnostics and therapeutics.
Shu-Yin Yuan, Qi Deng, Hong-Juan Gao et al.· Frontiers in Cell and Develo...· 0 citations
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