Sep 2026
Notoginsenoside R1 attenuates post-ischemic pyroptosis: a novel CKLF1-endoplasmic reticulum stress pathway-mediated mechanism.
BACKGROUND Ischemic stroke induces neuronal pyroptosis driven by excessive endoplasmic reticulum (ER) stress, which exacerbates secondary brain injury. Notoginsenoside R1 (NGR1) has demonstrated neuroprotective properties; however, whether its mechanism involves the modulation of chemokine-like factor 1 (CKLF1)-mediate...
Han-Long Wang, Yang Sun, Sha-Sha Liu et al.
· Phytomedicine · 0 citations