Review
Open access
Oct 2026
Beta-cell replacement for type 1 diabetes: integrating cell products, engraftment and immune protection
Beta-cell replacement aims to restore endogenous, glucose-responsive insulin secretion in type 1 diabetes. Donor-islet transplantation has shown that this approach can improve glycaemic control and prevent severe hypoglycaemia. Its wider use is limited by donor supply, early graft loss and chronic systemic immunosuppre...
Lan Chen, Xin-Hao Hu, Chen Zheng et al.
· Frontiers in Endocrinology · 0 citations