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Open access Sep 2026

Targeting the AKT2-NAMPT phosphorylation axis prevents macrophage senescence to enhance bactericidal activity in septic immunosuppression.

A dual-layer regulatory mechanism in which DDX6 controls NAMPT abundance, whereas AKT2 dictates its activity drives senescence during immune tolerance is identified, identifying AKT2-NAMPT as a potential therapeutic axis to restore immune competence in sepsis.

Qi-Lan Li, Mei He, Pei-Lin Shi et al. · 0 citations

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