Base and Nucleophilic Catalysis Enables Formal [3+2] Cycloaddition of Alkynyl Diazoketones and Aminomalonates: Access to γ,γ-Disubstituted 3-Pyrrolin-2-ones.
A formal [3+2] cycloaddition of alkynyl diazoketones with aminomalonates has been developed, providing rapid access to highly substituted γ,γ-disubstituted 3-pyrrolin-2-ones. This transformation proceeds under mild conditions with broad substrate scope and good functional-group tolerance, providing a practical approach...