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Qi-Long Wu

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Open access Sep 2026

Estrogen deprivation exacerbates Alzheimer’s disease pathology through neuronal CTSS signaling

Alzheimer’s disease (AD) exhibits a pronounced sex bias, with women facing disproportionately higher risk and more severe pathology. Postmenopausal estrogen decline is implicated in this vulnerability, yet the molecular mechanisms linking estrogen loss to AD pathogenesis remain incompletely understood. Here, we demonst...

Ren-Zhi Yang, Lin Shao, Fang Huang et al. · 0 citations

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