In vivo generation of CD19 CAR T cells for the treatment of mouse systemic lupus erythematosus.
OBJECTIVE Systemic lupus erythematosus (SLE) is a severe autoimmune disease with significant health impacts, yet effective therapies remain elusive. Recent advances underscore the promise of chimeric antigen receptor (CAR) T-cell therapy for SLE. However, conventional CAR T cells manufacturing is complex, limiting its...