Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with a high disability rate. Its core pathogenesis involves immune dysregulation, characterized notably by the aberrant polarization of macrophages toward the pro-inflammatory M1 phenotype, along with the abnormal proliferation and invasion...
Yao Wang, Meng Lin, Qi Sun et al.· International Journal of Nan...· 0 citations
Selective discrimination of glycosaminoglycans (GAGs) is crucial for drug safety and quality control but remains challenging because GAGs share similar disaccharide repeating units and overlapping polyanionic features. Nanozyme-based sensor arrays offer a cross-reactive fingerprinting strategy, yet many require multi...
Si-Jie Li, Qing Cheng, Qi Sun et al.· Analytical Chemistry· 0 citations
Acidity, hypoxia, redox imbalance, and altered enzyme activity in the tumor microenvironment (TME) can be used to regulate nanocarrier structure and drug release. However, these conditions vary among tumors and across regions within individual tumors and overlap with certain normal physiological and inflammatory proces...
Xiu-Lin Wen, Yong-Xin Jiang, Han-Jing Yang et al.· Journal of Nanotheranostics· 0 citations
The lack of vascular and neural innervations in cartilage often results in poor drug delivery and penetration, compromising the efficacy of current therapeutics. To tackle this clinical challenge, we designed positively charged manganese-doped CeO2 nanozymes that combine reactive oxygen species (ROS)-scavenging activ...
