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Jul 2026

Systematic Scanning Mutagenesis Unveils the Structure-Function Landscape Enabling Aptamer Evolution.

A structure-function landscape for aptamers is introduced, constructed by systematic single-point mutagenesis that maps the contribution of each nucleotide to target binding and highlights its potential to guide the development of high-performance biosensors.

Zhuoer Chen, Qi Sun, Xian-Lu Lei et al. · 0 citations

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