Qi-Wang He

Proteome-wide Mendelian randomization and transcriptome analysis of a novel osteoarthritis blood-targeting USP8, single-cell model and experimental validation.

BACKGROUND Osteoarthritis (OA) is the most common chronic joint disorder and greatly affects quality of life and increases socioeconomic burden; however, effective prevention is limited. Blood proteins with established causal evidence can probably serve as potential drug targets, but few have been causally linked with...