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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Qi-Xia Kuang

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Review Open access Sep 2026

TREM2-directed therapy in Alzheimer’s disease: from therapeutic window to clinical translation

It is proposed that the therapeutic value of TREM2 is best understood through the concept of therapeutic window, and soluble TREM2 (sTREM2) should be interpreted cautiously, as it may reflect receptor shedding, target engagement, microglial state, disease stage, or a combination of these processes rather than serving a...

Qi-Xia Kuang, Shu-Jun Li, Wen-Di Huang et al. · 0 citations

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