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Review Open access Jul 2026

Endocrine-metabolic imbalance drives osteoarthritis: From whole-joint pathobiology to precision therapy (Review)

Osteoarthritis (OA) is a chronic degenerative joint disease closely associated with aging and metabolic dysfunction, characterized by cartilage degeneration, synovial inflammation, aberrant subchondral bone remodeling, pain and progressive functional impairment. Beyond mechanical loading, accumulating evidence indicate...

Ruhui Yang, Haimin Zeng, Qi Xiao et al. · 1 citation

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