Transforming Growth Factor β3 (TGF-β3) Signaling: A Potential Target for Cancer Therapy.
Transforming growth factor β (TGF-β) signaling is essential for early embryonic development, tissue and organ formation, immune surveillance, tissue repair, and maintaining homeostasis in adults. The three isoforms of TGF-β, TGF-β1/2/3, share a structurally conserved secretion signal peptide and activate various downst...