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Case report Open access Oct 2026

Ivonescimab combined with radiotherapy in the treatment of advanced lung adenocarcinoma with high expression of PD-L1: A case report

The optimal sequencing of immunotherapy and radiotherapy in non-small cell lung cancer (NSCLC) remains unclear. The present study reports a case of advanced lung adenocarcinoma (cT4N2bM1a, stage IVa) with a programmed death-ligand 1 (PD-L1) tumor proportion score of 90% and TP53 mutation. The patient received first-lin...

Qi Zhou, Bo Yang, Hong-Yi Cai et al. · 0 citations
Review Open access Sep 2026

A systematic review and network meta-analysis of first-line EGFR-TKI-based combination strategies for EGFR-mutant non-small cell lung cancer with brain metastases

Brain metastases are common in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) and remain clinically challenging despite the improved central nervous system activity of third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs). Because direct comparisons between active first-line c...

Jia-Yu Ma, Wei-Xin Zhao, Wan-Jing Guo et al. · 0 citations

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