Qi-Zhu Tang

Eriodictyol targets the ubiquitination/phosphorylation of apoptosis signal-regulating kinase 1 and alleviates pressure-overload induced myocardial fibrosis in mice.

BACKGROUND AND PURPOSE Myocardial fibrosis, a critical pathogenic driver of cardiovascular events, is primarily characterized by extracellular matrix deposition and cardiac fibroblast proliferation and activation. Eriodictyol (ERIO) is an extractable natural compound widely found in fruits and vegetables, possessing po...

SRPK3 exacerbates cardiac ischemia/reperfusion injury by regulating KLF3-mTOR/P70 S6K-mediated autophagy.

Myocardial ischemia-reperfusion (I/R) injury remains a leading cause of cardiac dysfunction and mortality worldwide. Serine/arginine-Rich Protein Kinase 3 (SRPK3) is highly expressed in cardiac muscle, yet its specific pathological role in I/R injury has not been fully characterized. In this study, we utilized cardiac-...

II‑induced apoptosis in H9c2 cardiac cells via restoring reactive oxygen species‑mediated decreases in the mitochondrial membrane potential