Aug 2026
Discovery of 2, 4-disubstituted pyrimidine derivatives as selective HIPK2 inhibitors for potential treatment of chronic kidney disease.
AF-1 and AF-2 represent antifibrotic candidates with a new chemical scaffold, submicromolar HIPK2 inhibitory activity, and improved subtype selectivity within the HIPK family for the treatment of CKD-associated renal fibrosis.
Xinlan Hu, Hanyi Ouyang, Chunyu Feng et al.
· European journal of medicina... · 0 citations