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Open access Oct 2026

Single-Cell Sequencing Reveals Androgen Deficiency Arrests Meibocyte Differentiation and Impairs EMC-Mediated Lipid Metabolism

Purpose To investigate the cellular dynamics of androgen-deficient meibomian gland dysfunction (MGD) and to elucidate the molecular mechanisms limiting the structural regenerative efficacy of topical dihydrotestosterone (DHT) treatment. Methods Single-cell RNA sequencing (scRNA-seq) was performed on meibomian glands fr...

S. Qian, Zi-Hao Liu, Mike Pan et al. · 0 citations
Open access Oct 2026

Detection of an EGFR L858R mutation following prolonged sequential ALK-TKI therapy in ALK-rearranged NSCLC: a case report

Anaplastic lymphoma kinase ( ALK )-rearranged non-small cell lung cancer (NSCLC) typically exhibits profound sensitivity to ALK tyrosine kinase inhibitors (TKIs). While sequential therapy with next-generation inhibitors has significantly improved long-term outcomes, acquired resistance remains an eventual challen...

Jun-Yue Deng, Juan Li, Yu-Hong Chen et al. · 0 citations

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