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Cyclovirobuxine Prevents Osteoclastogenesis and Estrogen Deficiency-Induced Bone Loss by Inhibiting ROS Generation via the PI3K/AKT/FOXO1 Pathway
This research investigates how CVB modulates osteoclast development and functional activity, and elucidates its underlying molecular mechanisms. Osteoclasts are pivotal mediators of bone matrix degradation and reconstruction, and their overactivation is an important mechanism in diseases such as osteoporosis. By extr...
Eriodictyol regulates LDHB to trigger mitophagy-mediated NLRP3 inflammasome inactivation as a therapeutic strategy for bone loss.
BACKGROUND Imbalance of bone homeostasis triggers abnormal activation of osteoclasts and impaired osteogenic function, which further exacerbates bone resorption, reduces bone mass, and ultimately induces bone loss. Eriodictyol (ERI) possesses a wide range of biological activities and can effectively inhibit excessive b...