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Genetic Correlation Between Brain Imaging Phenotypes and Externalizing Behavior: A Large-Scale LDSC Analysis of UK Biobank IDPs
No statistically robust evidence of global genetic correlations between externalizing and individual UK Biobank brain imaging phenotypes was found and small, localized, mixed-direction, or developmentally specific genetic effects remain possible.
An Initial Genetic Correlation Analysis of Externalizing Behavior and Neuroimaging Phenotypes in the ABCD Cohort
Although several associations reached nominal significance, none remained significant after correction for multiple comparisons and the precision of the estimates was constrained by the available imaging GWAS sample size, uncertainty in SNP-heritability estimates, and the large number of regional comparisons.