The long-standing challenge of seasonal influenza vaccines providing poor protection is attributed to the rapid and continuous evolution of the virus. In theory, the recommendation of vaccine strain is to predict the dominant strain with best fitness in the upcoming season. Here, we develop FutureFlu, a biologically-gr...
Lu-Yao Qin, Meng-Yi Zhang, Xiao-Yuan Liu et al.· bioRxiv· 0 citations
With the rapid advancement of mRNA vaccines, lipid nanoparticles (LNPs) have emerged as pivotal carriers and adjuvants for non-mRNA vaccine modalities, driven by their superior nucleic acid delivery efficiency and intrinsic self-adjuvanting properties. In this study, we systematically evaluated various formulation stra...
Ning Luan, Han Cao, Xiaolong Zhang et al.· bioRxiv· 0 citations
Recombinant vesicular stomatitis virus (rVSV) is an increasingly popular vaccine vector, but it still faces challenges such as difficulties in construction, low in vitro amplification titers, safety concerns, and uncertain mucosal immune effects. Therefore, there is an urgent need to construct new VSV vectors for next-...
Ziteng Liang, Meng-Yi Zhang, Jie Zhang et al.· Signal Transduction and Targ...· 0 citations
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