Open access
Aug 2026
FAP-targeted ROS-responsive nanoparticles delivering siBTF3 modulate the TME to enhance immunotherapy in colorectal cancer
An intelligent nanodelivery system that may modulate the tumor-suppressive immune microenvironment by targeting and silencing BTF3 in CAFs is developed, suggesting potential additive benefit with immune checkpoint blockade therapy and offering preliminary evidence for a potential strategy to enhance immunotherapy for C...
Fei-Hu Yan, Zheng-Chun Kang, Dong-Wei Su et al.
· Journal of Translational Med... · 0 citations