UPLC-MS/MS-Based Analysis of the Impact of Polypharmacy on Quetiapine Plasma Concentrations.
Quetiapine, a second-generation atypical antipsychotic, has broad indications and considerable variation in daily prescribed doses across different diseases, yet its therapeutic window remains narrow (100-500 ng/mL). In clinical practice, quetiapine is frequently co-administered with other psychotropic drugs. To evalua...