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Author

Qian-Yuan Gong

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Sep 2026

PARP1-targeting PROTAC attenuates alcohol-associated liver injury and ileal epithelial damage.

Alcohol-associated liver disease (ALD) is driven by oxidative stress, inflammation, hepatocyte death, and intestinal barrier disruption, yet targeted pharmacological options remain limited. Here, we investigated LB23, a proteolysis-targeting chimera designed to degrade poly (ADP-ribose) polymerase 1 (PARP1), in cellula...

Qian-Yuan Gong, Jian-Yu Liu, Hua-Cui Li et al. · 0 citations

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