Jul 2026
Design and synthesis of neomycin-oxazolidinone hybrid antibiotics: exhibiting synergistic activity against Pseudomonas aeruginosa via outer membrane disruption.
Antibiotic resistance among multidrug-resistant pathogens has become a major global health challenge, highlighting the urgent need for new antibacterial strategies beyond conventional bactericidal agents. In this study, we designed and synthesized 14 neomycin-oxazolidinone hybrid antibiotics, comprising one direct neom...
Yinzhe Chen, Wei-Ding Wang, Wen-Bo Lu et al.
· Bioorganic chemistry (Print) · 0 citations