NUPR1-positive tumor-associated macrophages facilitate the progression of hepatocellular carcinoma via ferroptosis resistance.
BACKGROUND Tumor-associated macrophages (TAMs) are major contributors to the immunosuppressive microenvironment of hepatocellular carcinoma (HCC). Nuclear protein 1 (NUPR1) is a stress-responsive regulator implicated in tumor progression; however, whether it functionally controls ferroptosis-associated stress adaptatio...