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Review Open access Oct 2026

CAR-T-centered sequential therapy: current status, challenges, and future clinical perspectives

Over recent years, chimeric antigen receptor T-cell (CAR-T) therapy has markedly improved outcomes for patients with relapsed or refractory hematological malignancies. Nevertheless, a substantial proportion of patients still experience relapse or progression after treatment, driven by factors including antigen escape,...

Lu-Chen Zhou, Cheng-Cheng Tian, Rui-Qiang Du et al. · 0 citations

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