Author

Qiang Ding

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Open access Aug 2026

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

A substantial proportion of hospitalized COVID-19 patients require ICU admission, often associated with an imbalance between antiviral responses and inflammatory signaling leading to uncontrolled cytokine secretion. The SARS-CoV-2 nucleocapsid (N) protein is a known immune antagonist, but its role in macrophage-driven...

Zhen-Lan Yao, Pablo A. Alvarez, Carolina Chavez et al. · Science Advances · 0 citations

Jul 2026

Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy.

This study establishes VIDA mRNA as a versatile, broadly applicable strategy for combating diverse viral threats.

Lin Li, Xiu-Li Yan, Hao-Yang Wang et al. · Cell · 3 citations

Open access Aug 2026

Nanobodies targeting SARS-CoV-2 papain-like protease exert dual antiviral and anti-inflammatory effects

It is demonstrated that nanobodies targeting the PLpro/ISG15 interface can achieve synergistic antiviral and immunomodulatory effects, providing a proof-of-concept for a novel therapeutic approach to combat SARS-CoV-2 and potentially other emerging coronaviruses.

Guo-Long Liu, Jian-Tao Chen, Fang Wu et al. · Journal of Virology · 0 citations