Targeting ACKR1+ Endothelial Cells Attenuates Pulmonary Fibrosis by Halting Monocytes Infiltration/Polarization and Endothelial-to-Mesenchymal Transition.
While microvascular abnormalities drive idiopathic pulmonary fibrosis (IPF), the pathogenic endothelial subpopulations and their specific molecular networks are poorly understood. By integrating single-cell and spatial transcriptomics, we identified a pathologically expanded ACKR1+ endothelial cell (EC) subpopulation t...