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Author

Qiang Sun

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Review Open access Oct 2026

Affibody-based approaches as potential therapeutics for breast cancer: mechanisms, applications, and future perspectives

Breast cancer presents a significant therapeutic challenge due to the substantial molecular and genetic diversity among its subtypes, thereby necessitating the development of refined intervention strategies. Macromolecular therapies, such as monoclonal antibodies, are often hindered by suboptimal biodistribution, restr...

R. Yao, Keghon Kasparian, Yi-Dong Zhou et al. · 0 citations
Review Sep 2026

Advances in single-cell and spatial multi-omics for deciphering the mechanisms of pan-organ metastasis in breast cancer.

Overall, single-cell and spatial multi-omics are reframing breast cancer metastasis as a dynamic, multi-stage, and tissue-shaped process, providing a foundation for future biomarker development and mechanism-guided therapeutic strategies.

Yang Qu, Juan Sun, Zi-Hao Wang et al. · 0 citations
Open access Jul 2026

Beyond ADCs: Antibody-encapsulated drug for targeted cancer therapy

Preclinical investigation of trastuzumab-encapsulated actinomycin D, a HER2-targeted AED, has demonstrated potent antitumor activity across cancer models with varying HER2 expression levels, alongside a favorable toxicity profile in animal models, position AED as a promising next-generation targeted cancer therapy that...

Lin-Rong Li, Armando E. Giuliano, Qiang Sun et al. · 0 citations

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